• Sampsa Vanhatalo

Sampsa Vanhatalo


27 Sept 2018


Peer-reviewed scientific articles 2013-2018


Stevenson NJ, Vanhatalo S. Designing a trial for neonatal seizure treatment. Semin Fetal Neonatal Med. 2018;23:213-217. doi: 10.1016/j.siny.2018.02.005. (invited review)

Nevalainen P, Marchi V, Metsäranta M, Lönnqvist T, Vanhatalo S, Lauronen L. Evaluation of SEPs in asphyxiated newborns using a 4-electrode aEEG brain monitoring set-up. Clin Neurophysiol Pract. 2018;30:122-126. doi: 10.1016/j.cnp.2018.06.003

Tapani KT, Vanhatalo S, Stevenson NJ. Time-varying EEG correlations improve automated neonatal seizure detection. Int J Neural Syst. 2018;1850030. doi: 10.1142/S0129065718500302

Tokariev A, Stjerna S, Lano A, Metsäranta M, Palva MJ, Vanhatalo S. Preterm birth changes networks of newborn cortical activity. Cereb Cortex 2018. doi: 10.1093/cercor/bhy100

Stevenson NJ., Lauronen L, Vanhatalo S. The effect of reducing EEG electrode number on the visual interpretation of the human expert for neonatal seizure detection. Clin Neurophysiol. 2018;129:265-270. doi: 10.1016/j.clinph.2017.10.031

Vanhatalo S, Palva M. Infraslow EEG activity. In Niedermeyr’s Electroencephalography. Basic principles, clinical applications and related fields. Seventh edition (Schomer & Lopes da Silva F, eds.) Lippincott Williams & Wilkins, Wolters Kluwer, Philadelphia, 2018; 799-808.



Stevenson NJ, Oberdorfer L, Koolen N, O’Toole JM, Werther T, Klebermass-Schrehof K, Vanhatalo S, Functional maturation in preterm infants measured by serial recording of cortical activity. Sci Rep. 2017;7:12969. doi: 10.1038/s41598-017-13537-3

Nevalainen P, Marchi V, Metsäranta M, Lönnqvist T, Toiviainen-Salo S, Vanhatalo S, Lauronen L. Evoked potentials recorded during routine EEG predict outcome after perinatal asphyxia. Clin Neurophysiol. 2017;128:1337-1343. doi: 10.1016/j.clinph.2017.04.025

O'Toole JM, Boylan GB, Lloyd RO, Goulding RM, Vanhatalo S, Stevenson NJ. Detecting bursts in the EEG of very and extremely premature infants using a multi-feature approach. Med Eng Phys. 2017;45:42-50. doi: 10.1016/j.medengphy.2017.04.003

Nevalainen P, Lauronen L, Metsäranta M, Lönnqvist T, Ahtola E, Vanhatalo S. Neonatal somatosensory evoked potentials persist during hypothermia. Acta Paediatr. 2017;106:912-917. doi: 10.1111/apa.13813

Ahtola E, Stjerna S, Stevenson NJ, Vanhatalo S. The use of eye tracking improves the detection of evoked responses to complex visual stimuli in the EEG of infants. Clin Neurophysiol Pract. 2017;2:81-90. doi: 10.1016/j.cnp.2017.03.002

Koolen N, Oberdorfer L, Rona Z, Giordano V, Werther T, Klebermass-Schrehof K, Stevenson N, Vanhatalo S. Automated classification of neonatal sleep states using EEG. Clin Neurophysiol. 2017;128:1100-1108. doi: 10.1016/j.clinph.2017.02.025

Smeds E, Vanhatalo S, Piitulainen H, Bourguignon M, Jousmäki V, Hari R. Corticokinematic coherence as a new marker for somatosensory afference in newborns. Clin Neurophysiol. 2017;128:647-655. doi: 10.1016/j.clinph.2017.01.006

Sairanen V, Kuusela L, Sipilä O, Savolainen S, Vanhatalo S. A novel measure of reliability in Diffusion Tensor Imaging after data rejections due to subject motion. NeuroImage 2017;147:57-65. doi: 10.1016/j.neuroimage.2016.11.061.



Vanhatalo S, Fransson P. Advanced EEG and MRI measurements to study the functional development of the newborn brain. In Prenatal & Postnatal Determinants of Brain Development: Recent Studies and Methodological Advances (Walker D., ed.). Springer, 2016; 53-68.

Stevenson NJ, Boylan G, Hellström-Westas L, Vanhatalo S. Treatment trials for neonatal seizures: the effect of design on sample size. PLoS One 2016;11:e0165693. doi:10.1371/journal.pone.0165693.

Videman M, Stjerna S, Roivainen R, Nybo T, Vanhatalo S, Gaily E, Leppänen JM. Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs. Epilepsy Behav. 2016;64:62-68. doi: 10.1016/j.yebeh.2016.09.023

Videman M, Tokariev A, Saikkonen H, Stjerna S, Heiskala H, Mantere O, Vanhatalo S. Newborn brain function is affected by fetal exposure to maternal serotonin reuptake inhibitors. Cereb Cortex 2016;27:3208-3216. doi: 10.1093/cercor/bhw153

O'Toole JM, Boylan GB, Vanhatalo S, Stevenson NJ. Estimating functional brain maturity in very and extremely preterm neonates using automated analysis of the electroencephalogram. Clin Neurophysiol. 2016;127:2910-8. doi: 10.1016/j.clinph.2016.02.024

Koolen N, Dereymaeker A, Räsänen O, Jansen K, Vervisch J, Matic V, Naulaers G, De Vos M, Van Huffel S, Vanhatalo S. Early development of synchrony in cortical activations in the human. Neuroscience 2016;322:298-307. doi: 10.1016/j.neuroscience.2016.02.017

Videman M, Tokariev A, Stjerna S, Roivainen R, Gaily E, Vanhatalo S. Effects of prenatal antiepileptic drug exposure on newborn brain activity. Epilepsia 2016;57:252-62. doi: 10.1111/epi.13281

Tokariev A, Vanhatalo S, Palva M. Analysis of infant cortical synchrony is constrained by the number of recording electrodes and the recording montage. Clin Neurophysiol. 2016;127:310-23. doi: 10.1016/j.clinph.2015.04.291

Tokariev A, Videman M, Palva JM, Vanhatalo S. Functional brain connectivity develops rapidly around term age and changes between vigilance states in the human newborn. Cereb Cortex 2016;26:4540-4550. doi: 10.1093/cercor/bhv219



Koolen N, Dereymaeker A, Rasanen O, Jansen K, Vervisch J, Matic V, De Vos M, Naulaers G, Van Huffel S, Vanhatalo S. Data-driven metric representing the maturation of preterm EEG. Conf Proc IEEE Eng Med Biol Soc. 2015;2015;1492-5. doi: 10.1109/EMBC.2015.7318653

Omidvarnia A, Metsäranta, M Lano A, Vanhatalo S. Structural damage in the early preterm brain changes the electric resting state networks. NeuroImage 2015;120:266-273. doi: 10.1016/j.neuroimage.2015.06.091

Stevenson NJ, Clancy RR, Vanhatalo S, Rosen I, Rennie JM, Boylan GB. Interobserver agreement for neonatal seizure detection using multichannel EEG. Ann Clin Transnl Neurol. (Annals of Neurology group), 2015;2:1002-11. doi: 10.1002/acn3.249

Iyer KK, Roberts JA, Hellstrom-Westas L, Wikström S, Hansen-Pupp I, Ley D, Breakspear M, Vanhatalo S. Early detection of preterm intraventricular hemorrhage from clinical electroencephalography. Crit Care Med. 2015;43:2219-27. doi: 10.1097/CCM.0000000000001190

Stjerna S, Lano A, Metsäranta M, Vanhatalo S. Cumulative deviance scores can be used as an alternative to the Hammersmith Neonatal Neurological Examination in scientific research. Acta Paediatr. 2015;104:e414-6. doi: 10.1111/apa.13066

Stjerna S, Sairanen V, Gröhn R, Andersson S, Metsäranta M, Lano A, Vanhatalo S. Visual fixation in human newborns correlates with extensive white matter networks and predicts long-term neurocognitive development. J Neurosci. 2015;35:4824-9. doi: 10.1523/JNEUROSCI.5162-14.2015

Matic V, Cherian PJ, Koolen N, Ansari AH, Naulaers G, Govaert P, Van Huffel S, De Vos M, Vanhatalo S Objective differentiation of neonatal EEG background grades using detrended fluctuation analysis. Front Hum Neurosci. 2015;9:189. doi: 10.3389/fnhum.2015.00189 9:189

Iyer KK, Roberts JA, Hellstrom-Westas L, Wikstrom S, Hansen-Pupp I, Ley D, Vanhatalo S, Breakspear M. Cortical burst dynamics predict clinical outcome early in extremely preterm infants. Brain 2015;138:2206-18. doi: 10.1093/brain/awv129

Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S. Neonatal seizure treatment with Medication Off-patent (NEMO) consortium. Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial. Lancet Neurol. 2015;14:469-77. doi: 10.1016/S1474-4422(14)70303-5

Rahkonen P, Lano A, Pesonen A-K, Heinonen K, Räikkönen K, Vanhatalo S, Autti T, Valanne K, Andersson S, Metsäranta M. Atypical sensory processing is common in extremely low gestational age children. Acta Paediatr. 2015;104:522-8. doi: 10.1111/apa

Gargiulo P, Vanhatalo S, Ramon C. The effect of fontanel on scalp EEG potentials in the neonate. Clin Neurophysiol. 2015;126:1703-10. doi: 10.1016/j.clinph.2014.12.002

Benders M, Palmu K, Menache C, Tas M, Lazeyras F, Sizonenko S, Dubois, Vanhatalo S, Huppi P. Early brain activity relates to brain growth during prematurity: A quantitative study of preterm neonatal EEG and MRI. Cereb Cortex 2015;25:3014-24. doi: 10.1093/cercor/bhu097 (S.V. last author with equal contribution)

Nevalainen P, Rahkonen P, Pihko E, Lano A, Vanhatalo S, Andersson S, Autti T, Valanne L, Metsäranta M, Lauronen L. Evaluation of somatosensory cortical processing in extremely preterm infants at term with MEG and EEG. Clin Neurophysiol. 2015;126:275-83. doi: 10.1016/j.clinph.2014.05.036



Roberts JA, Iyer KK, Vanhatalo S and Breakspear M. Critical role for resource constraints in neural models. Front. Syst. Neurosci. 2014; 8:154. doi: 10.3389/fnsys.2014.00154

Koolen N, Dereymaeker A, Räsänen O, Jansen K, Vervisch J, Matic V, De Vos M, Van Huffel S, Naulaers G, Vanhatalo S. Interhemispheric synchrony in the neonatal EEG revisited: activation synchrony index as a promising classifier. Front Hum Neurosci 2014;8:1030. doi: 10.3389/fnhum.2014.01030.

Stevenson N, Palmu K, Wikström S, Hellström-Westas L, Vanhatalo S. Measuring brain activity cycling (BAC) in long term EEG monitoring of preterm babies. Physiol Meas. 2014;35:1493-508. doi: 10.1088/0967-3334/35/7/1493

Odabaee M, Tokariev A, Layeghy S, Mesbah M, Colditz PB, Ramon C, Vanhatalo S. Neonatal EEG at scalp is focal and implies high skull conductivity in realistic neonatal head models. Neuroimage 2014;96C:73-80. doi: 10.1016/j.neuroimage.2014.04.007

Ahtola E, Stjerna S, Yrttiaho S, Nelson C, Leppänen J, Vanhatalo S. Dynamic eye tracking based metrics for infant gaze patterns in the face-distractor competition paradigm. PLoS One 2014;9:e97299. doi: 10.1371/journal.pone.0097299

Roberts JA, Iyer KK, Finnigan S, Vanhatalo S, Breakspear M. Scale-free bursting in human cortex following hypoxia at birth. J Neurosci. 2014;34:6557-72. doi: 10.1523/JNEUROSCI.4701-13.2014

Iyer KK, Roberts JA, Metsäranta M, Finnigan S,Breakspear M, Vanhatalo S. Novel features of early burst suppression predict outcome after birth asphyxia. Ann Clin Transl Neurol. (Annals of Neurology group). 2014;1:209-14. doi: 10.1002/acn3.32

Peltola ME, Sairanen V, Gaily E, Vanhatalo S. Measuring spike strength in patients with CSWS: comparison of methods for prospective use as a clinical index. Clin Neurophysiol. 2014;125:1639-46. doi: 10.1016/j.clinph.2013.12.093

Vanhatalo S, Alnajjar A, Vinh N, Colditz P, Fransson P, Maillet D. Safety of EEG–fMRI recordings in newborn infants at 3T: A study using a baby-size phantom. Clin Neurophysiol. 2014;125:941-6. doi: 10.1016/j.clinph.2013.09.041

Omidvarnia A, Azemi G, Boashash B, O’ Toole JM, Colditz P, Vanhatalo S. A novel measure of time-varying information flow for scalp EEG signals: Orthogonalized Partial Directed Coherence. IEEE Trans Biomed Eng. 2014;61:680-93. doi: 10.1109/TBME.2013.2286394

Omidvarnia A, Fransson P,Metsäranta M, Vanhatalo S. Functional bimodality in the brain networks of preterm and term human newborns. Cereb Cortex 2014;24:2657-68. doi: 10.1093/cercor/bht120

Malk K, Metsäranta M, Vanhatalo S. Drug effects on endogenous brain activity in preterm babies. Brain Dev. 2014;36:116-23. doi: 10.1016/j.braindev.2013.01.009



Palmu K, Kirjavainen T, Salokivi T, Stjerna S, Vanhatalo S. Sleep wake cycling in early preterm infants: Comparison of polysomnographic recordings with a novel EEG-based index.Clin Neurophysiol. 2013;124:1807-1814. doi: 10.1016/j.clinph.2013.03.010

Boylan G, Stevenson N, Vanhatalo S. Monitoring neonatal seizures. Semin Fetal Neonatal Med. 2013;18:202-208. (invited review) doi: 10.1016/j.siny.2013.04.004

Kontio T, Toet MC. Hellström-Westas L, van Handel M, Groenendaal F, Stjerna S, Vanhatalo S, de Vries LS. Early neurophysiology and MRI in predicting neurological outcome at 9-10 years after birth asphyxia. Clin Neurophysiol. 2013;124:1089-94. doi: 10.1016/j.clinph.2012.12.045

Räsänen O, Metsäranta M, Vanhatalo S. Development of a novel robust measure for interhemispheric synchrony in the neonatal EEG: Activation Synchrony Index (ASI). NeuroImage 2013;69:256-266. doi: 10.1016/j.neuroimage.2012.12.017

Rahkonen P, Nevalainen P, Lauronen L, Pihko E, Lano A, Vanhatalo S, Pesonen A-K, Heinonen K, Räikkönen K, Valanne L, Autti T, Lano A, Andersson S, Metsäranta M. Cortical somatosensory processing measured by magnetoencephalography predicts neurodevelopment in extremely low gestational age infants. Pediatr Res. 2013;73:763-71. doi: 10.1038/pr.2013.46

Odabaee M, Freeman W, Colditz P, Ramon C, Vanhatalo S. Spatial patterning of the neonatal EEG suggests a need for a high number of electrodes. NeuroImage 2013;68:229-235. doi:10.1016/j.neuroimage.2012.11.062



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